Fibromyalgia Mechanism Of Action

FIBROMYALGIA Mechanism of action:

Research has shown that the walls of the capillaries feeding blood and oxygen to affected muscles become thickened and are unable to deliver enough oxygen to fully supply the tissue in patients with fibromyalgia. This lack of oxygen creates localized ischemia and drains the energy pools in the affected muscle. Energy depletion then unleashed a cascade of physiological events leading to severe pain, muscle stiffness, soreness, and overwhelming fatigue. One of the major impacts of the energy deprivation associated with fibromyalgia is the muscle’s inability to manage it’s calcium load. The lack of cellular energy inhibits the activity of the cellular calcium pumps, so calcium cannot be adequately discharged from the cell following contraction. The buildup of calcium in the cell sustains the contraction and keeps the muscle tense. The increase in intracellular calcium also causes potassium ions to rush out of the cell, activating pain receptors on the cell membranes called nociceptors. The pain cause by nociceptor activation causes further tightening of the muscles, contributing further to muscle stiffness and exacerbating the drain on energy reserves. So the downward spiral continues. p. 154


Dr Sinatra has developed several schemes for age management, high blood pressure, arrhythmias, mitral valve prolapse, congestive cardiac failure, syndrome X, for professional and world class athletes, but also for fibromyalgia, chronic fatigue syndrome and mitochondrial cytopathies. He recommends the following daily cocktail for CFS:

Co-enzyme Q 10 300 – 360mg (the oil of the engine, this moves electrons from one molecule to another)
L-carnitine 2,000 – 3,000mg (the oil of the engine, this moves ATP and ADP across mito membranes)
D-ribose 15grams (the raw material to make new ATP) 5 grams x 3 with meals
Magnesium 400 – 800mg (the spark plugs, this fires up many enzyme reactions)

Reference:
The Sinatra Solution Metabolic Cardiology by Stephen T Sinatra. ISBN 1-59120-158-

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